Multiple Discoveries in Causal Inference: LATE for the Party

Editor’s Note: The opinions expressed by the authors are their own, and this material should not be interpreted as representing the official viewpoint of the US Department of Health and Human Services, National Institutes of Health, National Cancer Institute, or the NCI Division of Cancer Prevention.

In 1994, economists Guido Imbens and Joshua Angrist formulated a causal model to estimate local average treatment effect, or LATE, which was a major factor in their winning the 2021 Nobel Prize in economics. In the same year, 1994, we published an independent formulation of LATE applied to medical research. The parallel development of LATE in these two settings and others offers insights into statistical research and multiple discoveries.

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