Meta-analysis: Can We Extract Gold from the Biomedical Literature?
Scientific investigation does not march to its conclusions on a straight and open road. Studies may be inconclusive, or even produce conflicting results. They may have defects in design or execution that leave their conclusions open to question. The body of completed studies addressing a particular question may vary considerably in critical aspects such as design, population, measurement, or clinical/experimental protocols, all of which may cloud the interpretation of results and make meaningful comparisons difficult. This process is further complicated by the sheer magnitude of the ever-expanding scientific literature.
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