Establishing a Culture of Reproducibility and Openness in Medical Research with an Emphasis on the Training Years

Examples of ethically misguided research remind us of the need for focusing on greater transparency and accountability in medical research. Fraudulent claims about links between vaccines and autism in a British study shook the medical community when The Lancet retracted the original 1998 article by A. J. Wakefield and colleagues. In another recent example, Nature Medicine retracted a 2006 paper claiming to determine patients’ sensitivity to chemotherapeutic drugs using gene expression, where neither the research nor the lead author, Anil Potti, were what they claimed to be.

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